References, Papers, Software and Demos related to...
Methods of Adjustment for Treatment
Selection Bias and Confounding
Obenchain RL. “Nearest Neighbors Analysis for PRRAP, the Probable Report Rate Analysis Plan.” TM-79-1711-4. Holmdel, NJ: AT&T Bell Laboratories. 1979. View/Download
Obenchain RL, Melfi CA. Propensity score and Heckman adjustments for treatment selection bias in database studies. 1997 Proceedings of the Biopharmaceutical Section. Alexandria, VA: American Statistical Association. 1998; 297-306. View/Download
Crown WE, Obenchain RL, Engelhart L, Lair TJ, Buesching DP, Croghan TW. The application of sample selection models in evaluating treatment effects: the case for examining the effects of antidepressant medication. Statistics in Medicine 1998; 17, 1943-1958. [Heckman conversion of propensity scores into inverse Mill's ratios.]
Kereiakes DJ, Obenchain RL, Barber BL, et al. Abciximab provides cost effective survival advantage in high volume interventional practice. Am Heart J 2000; 140: 603-610. [Propensity score binning.] Paper Technical Appendix
Tai-Seale M, Croghan TM, Obenchain RL. Determinants of antidepressant treatment compliance: implications for policy. Medical Care Research and Review 2000; 57: 491-512. [Propensity score binning with 3 or more treatment choices.]
Hall JA, Summers KH, Obenchain RL. Cost and utilization comparisons among propensity score matched insulin lispro and regular insulin users. Journal of Managed Care Pharmacy 2003; 3: 263-268. [Propensity score matching.]
Obenchain RL. Unsupervised Propensity Scoring: NN and IV Plots. 2004 JSM Proceedings on CD-ROM. (8 pages.) Alexandria, VA: American Statistical Association. 2005. View/Download
Chen K, Chang EY, Summers KH, Obenchain RL, Yu-Isenberg KS, Sun P. Comparison of Costs and Utilization Between Users of Insulin Lispro Versus Users of Regular Insulin in a Managed Care Setting. Journal of Managed Care Pharmacy 2005; 11(5): 376-382. [Propensity score binning.]
Obenchain RL. USPS: R package for Unsupervised and Supervised Propensity Scoring and Instrumental Variable Adjustment. 2006-2009. CRAN, Packages @ http://www.r-project.org Or... Download Windows package from this site
Obenchain RL. JMP Scripts for “Local Control” Phases One and Two. 2006-2010. Newest Update for JMP 8 (Version 2010_06): Download Archive of JMP Scripts, Documentation and Data
Obenchain RL. Identifying Meaningful Patient Subgroups via Clustering - Sensitivity Graphics. 2006 JSM Proceedings on CD-ROM. (6 pages.) Alexandria, VA: American Statistical Association. 2007. View/Download
Obenchain RL. The "LC Carousel" Archive ...an Adobe Flash animation describing the activities within the Four Phases of a Local Control analysis that assure results will ultimately be objective (scientifically valid.) Updated May 2010. Download ZIP Archive
Obenchain RL. Analysis of Observational Studies: An In-depth Review of Methods of Adjustment for Treatment Selection Bias and Confounding. Unfinished Draft White Paper. September 2009. View/Download
Obenchain RL. "The Local Control Approach using JMP." Chapter 7 of Analysis of Observational Health Care Data Using SAS. Cary, NC; SAS Press, January 2010. View/Download Chapter 7 Outline (Figures in Color) Purchase a copy of the book from SAS or Amazon!!!
Obenchain RL. SAS Macros (OMOP Version 1.4) for “Local Control” Phases One and Two. [Copyright (c) 2009, Foundation for the National Institutes of Health; Apache 2.0 License.] August 2011 Update: Download SAS Macros, Doc PDF and Data Archive
Obenchain RL. LC_intro.PDF - Copies of my web pages about the Local Control approach. Updated: May 2010. View/Download
Obenchain RL. LC_ADJ_BIAS.PDF - Newest Local Control presentation -- ACTS pre-meeting, Joint Statistical Meetings, Miami, August 2011. View/Download
Obenchain RL. PS_FINER.PDF - Beyond Propensity Scores: What could be Finer? -- HPSS Roundtable Discussion, Joint Statistical Meetings, Miami, August 2011. View/Download